More and more people are choosing to enhance their appearance to reduce the visibility of wrinkles and discoloration. Some opt for surgery, while others prefer less invasive treatments—such as biostimulant injections. These collagen- or hyaluronic acid-based substances should be administered to patients multiple times, with at least a two-week interval between sessions. Our aesthetic medicine wholesale store offers a wide selection of such products, suitable for use on the face, neck, décolletage, and hands.
Recent studies have led to the development of innovative ingredient combinations that can be applied directly to the dermis. As a result, biostimulators do not require surgical procedures for their active ingredients to reach deeper layers of the skin. Our store offers both single products and complete sets with various concentrations of polynucleotides and viscosity levels.
How to restore dull and tired skin already showing signs of aging? Tissue stimulators help regain a fresh and radiant complexion. We offer formulations that rebuild skin structure while also hydrating and lifting. They exhibit antioxidant properties and come from trusted industry manufacturers, including Bioceris, DIVES, MEDISEPTE, Professional Dietetics, and PROMOITALIA. Our offer is aimed at beauty salons, spas, and aesthetic medicine clinics.
Tissue Stimulators – Hydration, Lifting, Antioxidation
What exactly are tissue stimulators? These are specialized formulations that regenerate the skin by rebuilding the “youth proteins” – collagen and elastin. Their production decreases with age, leading to deterioration of skin quality. While aging is inevitable, it can be effectively slowed down thanks to products that restore the skin’s structure. They are intended for individuals who want to smooth out visible wrinkles and folds, improve skin elasticity, and lift the sagging facial contour.
Tissue stimulator formulas are carefully developed and typically based on:
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Non-crosslinked hyaluronic acid, which restores the skin’s water balance
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PDRN (polydeoxyribonucleotide), a component that intensively regenerates the skin
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Niacinamide (Vitamin B3), which has strong moisturizing and antioxidant properties
These products are used in anti-aging cosmetology to rebuild and regenerate the skin's structure. The active ingredients improve skin density and quality, making them among the most effective substances in rejuvenation therapy.
Tissue Stimulators at LipStore – From Karisma, Nucleofill, and Profhilo
In the case of tissue stimulators, the rebuilding formula targets the signs of aging. Some products combine hyaluronic acid with polynucleotides, providing excellent hydration, smoothing wrinkles, and revitalizing the skin. They are also suitable for sensitive areas like the under-eye region and tear troughs. These anti-aging solutions help reduce drooping eyelids and under-eye bags.
Benefits of Tissue Stimulators
Tissue stimulators are widely appreciated by professionals in the beauty industry and their clients alike, thanks to their numerous advantages:
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High effectiveness – Products like Ejal 40 show results after just one treatment with minimal injections. For best results, a series of treatments is recommended at manufacturer-specified intervals
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Long-lasting effects – After the full recommended course, results can last up to 3 years, with occasional maintenance treatments
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Comprehensive action – These products contain compounds such as non-crosslinked hyaluronic acid, DNA nucleotides, and succinic acid. They stimulate skin regeneration, nourish, restore volume, and improve elasticity
Despite their powerful results, tissue stimulators are very safe, with minimal pain, no recovery time, and no special preparation required.
Tissue Stimulators vs. Fillers
Tissue stimulators like Karisma, Nucleofill, and others are often mistaken for fillers. While they may offer similar visual results, they are fundamentally different:
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Tissue stimulators contain non-crosslinked hyaluronic acid made up of small molecules. This allows for deep hydration and stimulation of skin regeneration. It’s metabolized quickly—remaining in the skin for about a month—though the results last longer.
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Fillers, on the other hand, use crosslinked hyaluronic acid, consisting of large, dense molecules that stay in place for up to 18 months. They are used for contouring specific facial features like lips, noses, or cheeks. While highly effective at altering appearance, fillers do not improve skin condition to the same degree as stimulators.
Contraindications for Tissue Stimulator Treatments
As with all medical products, tissue stimulators should not be used under certain conditions, including:
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Pregnancy and breastfeeding
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Autoimmune diseases or blood clotting disorders
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Skin inflammation
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HIV or hepatitis infections
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Cancer
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Allergy to hyaluronic acid or other ingredients
Treatments should also be avoided during recovery from procedures like microdermabrasion or botox. A thorough consultation is required prior to treatment.
Choose Professional Quality – Tissue Stimulators from Karisma, Nucleofill, and Profhilo
Our range includes the most trusted and effective tissue stimulators on the market. Brands like Profhilo, Karisma, and Nucleofill provide outstanding safety and performance, helping you deliver exceptional results to your clients and build your professional reputation. Choosing these products is a smart investment in the future of your beauty business.